| 1. Journée | 14.08.2011 | River Plate | - | Nacional | 3:3 | ||||
| 2. Journée | 21.08.2011 | Liverpool | - | River Plate | 1:2 | ||||
| 3. Journée | 27.08.2011 | River Plate | - | Rentistas | 2:0 |  |
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| 4. Journée | 04.09.2011 | Montevideo Wanderers | - | River Plate | 0:3 | |
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| 5. Journée | 11.09.2011 | River Plate | - | Rampla Juniors | 2:1 | ||||
| 6. Journée | 18.09.2011 | Cerrito | - | River Plate | 0:0 | ||||
| 7. Journée | 24.09.2011 | River Plate | - | Peñarol | 0:4 | ||||
| 8. Journée | 02.10.2011 | CA Cerro | - | River Plate | 2:0 | ||||
| 9. Journée | 09.10.2011 | River Plate | - | Cerro Largo | 2:1 | ||||
| 10. Journée | 15.10.2011 | Fénix | - | River Plate | 1:2 | |
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| 11. Journée | 06.11.2011 | River Plate | - | Bella Vista | 1:2 | ||||
| 12. Journée | 12.11.2011 | Danubio | - | River Plate | 0:0 | ||||
| 13. Journée | 19.11.2011 | El Tanque Sisley | - | River Plate | 1:1 | ||||
| 14. Journée | 26.11.2011 | River Plate | - | Racing | 2:1 | |
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| 15. Journée | 02.12.2011 | Defensor Sporting | - | River Plate | 0:2 |
Uruguay