| 2. Journée | 14.02.2022 | Peñarol | - | Defensor Sporting | 0:1 | ||||
| 3. Journée | 19.02.2022 | Defensor Sporting | - | Montevideo City Torque | 1:3 |  |
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| 5. Journée | 12.03.2022 | Defensor Sporting | - | Plaza Colonia | 0:0 | |
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| 6. Journée | 21.03.2022 | Boston River | - | Defensor Sporting | 1:1 | ||||
| 7. Journée | 03.04.2022 | Defensor Sporting | - | River Plate | 3:2 | ||||
| 8. Journée | 09.04.2022 | Cerro Largo | - | Defensor Sporting | 0:0 | |
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| 9. Journée | 16.04.2022 | Defensor Sporting | - | Fénix | 2:1 |  |
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| 10. Journée | 26.04.2022 | Defensor Sporting | - | Cerrito | 0:0 | ||||
| 11. Journée | 07.05.2022 | Albion | - | Defensor Sporting | 0:3 | ||||
| 12. Journée | 14.05.2022 | Defensor Sporting | - | Nacional | 0:2 | ||||
| 13. Journée | 22.05.2022 | Danubio | - | Defensor Sporting | 1:2 | ||||
| 14. Journée | 29.05.2022 | Defensor Sporting | - | Deportivo Maldonado | 1:1 | |
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| 15. Journée | 05.06.2022 | Rentistas | - | Defensor Sporting | 1:0 |
Argentine