| 10. Journée | 27.10.2021 | Cagliari Calcio | - | AS Roma | 1:2 | ||||
| 11. Journée | 31.10.2021 | AS Roma | - | AC Milan | 1:2 | ||||
| 13. Journée | 21.11.2021 | Genoa CFC | - | AS Roma | 0:2 |  |
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| 17. Journée | 13.12.2021 | AS Roma | - | Spezia Calcio | 2:0 |  |
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| 19. Journée | 22.12.2021 | AS Roma | - | Sampdoria | 1:1 | ||||
| 20. Journée | 06.01.2022 | AC Milan | - | AS Roma | 3:1 | ||||
| 21. Journée | 09.01.2022 | AS Roma | - | Juventus | 3:4 | ||||
| 22. Journée | 16.01.2022 | AS Roma | - | Cagliari Calcio | 1:0 | |
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| 23. Journée | 23.01.2022 | Empoli FC | - | AS Roma | 2:4 | ||||
| 24. Journée | 05.02.2022 | AS Roma | - | Genoa CFC | 0:0 | ||||
| 25. Journée | 13.02.2022 | Sassuolo Calcio | - | AS Roma | 2:2 | ||||
| 26. Journée | 19.02.2022 | AS Roma | - | Hellas Verona | 2:2 | ||||
| 28. Journée | 05.03.2022 | AS Roma | - | Atalanta | 1:0 | ||||
| 29. Journée | 13.03.2022 | Udinese Calcio | - | AS Roma | 1:1 | |
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| 32. Journée | 10.04.2022 | AS Roma | - | US Salernitana 1919 | 2:1 | ||||
| 33. Journée | 18.04.2022 | SSC Napoli | - | AS Roma | 1:1 | ||||
| 35. Journée | 01.05.2022 | AS Roma | - | Bologna FC | 0:0 |
Ghana