| 2. Journée | 31.07.2022 | Plaza Amador | - | Sporting San Miguelito | 1:1 |  |
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| 3. Journée | 08.08.2022 | Sporting San Miguelito | - | Árabe Unido | 0:0 | ||||
| 4. Journée | 11.08.2022 | Sporting San Miguelito | - | Tauro FC | 3:1 | |
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| 5. Journée | 14.08.2022 | Potros del Este | - | Sporting San Miguelito | 1:3 | ||||
| 7. Journée | 28.08.2022 | Herrera FC | - | Sporting San Miguelito | 0:0 | ||||
| 8. Journée | 03.09.2022 | Sporting San Miguelito | - | Veraguas United | 3:2 | ||||
| 9. Journée | 12.09.2022 | Sporting San Miguelito | - | San Francisco FC | 2:1 | ||||
| 11. Journée | 24.09.2022 | Independiente de La Chorrera | - | Sporting San Miguelito | 0:2 | |
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| 13. Journée | 02.10.2022 | Sporting San Miguelito | - | Plaza Amador | 1:1 | ||||
| 14. Journée | 08.10.2022 | Árabe Unido | - | Sporting San Miguelito | 1:1 | |
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| 16. Journée | 22.10.2022 | Sporting San Miguelito | - | Potros del Este | 3:2 |
Colombie