| 4. Journée | 30.07.2021 | River Plate II | - | Huracán II | 2:0 |  |
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| 8. Journée | 23.08.2021 | River Plate II | - | Aldosivi II | 3:0 | |
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| 9. Journée | 31.08.2021 | Sarmiento de Junín II | - | River Plate II | 3:1 | ||||
| 10. Journée | 06.09.2021 | River Plate II | - | Independiente II | 4:0 | ||||
| 11. Journée | 10.09.2021 | Newell's Old Boys II | - | River Plate II | 0:2 | ||||
| 12. Journée | 17.09.2021 | River Plate II | - | Arsenal de Sarandí II | 0:1 | ||||
| 13. Journée | 24.09.2021 | Central Córdoba SdE II | - | River Plate II | 1:2 | ||||
| 17. Journée | 20.10.2021 | Talleres de Córdoba II | - | River Plate II | 1:0 | ||||
| 19. Journée | 31.10.2021 | Estudiantes II | - | River Plate II | 0:0 | ||||
| 20. Journée | 05.11.2021 | River Plate II | - | Patronato de Paraná II | 2:0 | ||||
| 23. Journée | 28.11.2021 | Rosario Central II | - | River Plate II | 2:0 | ||||
| 24. Journée | 03.12.2021 | River Plate II | - | Defensa y Justicia II | 2:1 | ||||
| 25. Journée | 10.12.2021 | Atlético Tucumán II | - | River Plate II | 1:1 |
Argentine