| 1. Journée | 06.02.2022 | Boston River | - | Plaza Colonia | 0:0 | ||||
| 2. Journée | 13.02.2022 | Boston River | - | Cerrito | 0:1 | ||||
| 9. Journée | 15.04.2022 | Danubio | - | Boston River | 0:0 |  |
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| 10. Journée | 24.04.2022 | Boston River | - | Deportivo Maldonado | 2:0 | ||||
| 11. Journée | 08.05.2022 | Rentistas | - | Boston River | 0:1 | ||||
| 12. Journée | 16.05.2022 | Boston River | - | Liverpool | 2:3 | ||||
| 13. Journée | 22.05.2022 | Peñarol | - | Boston River | 1:0 | |
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| 14. Journée | 28.05.2022 | Boston River | - | Montevideo City Torque | 3:1 | ||||
| 15. Journée | 06.06.2022 | Montevideo Wanderers | - | Boston River | 1:2 |
Uruguay