| 3. Journée | 01.02.2021 | Defensor Sporting | - | River Plate | 0:2 | ||||
| 10. Journée | 28.02.2021 | Defensor Sporting | - | Danubio | 1:1 |  |
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| 11. Journée | 08.03.2021 | Nacional | - | Defensor Sporting | 2:1 | |
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| 12. Journée | 12.03.2021 | Defensor Sporting | - | Boston River | 1:2 | ||||
| 13. Journée | 18.03.2021 | Deportivo Maldonado | - | Defensor Sporting | 2:1 | ||||
| 14. Journée | 25.03.2021 | Defensor Sporting | - | Rentistas | 0:0 | ||||
| 15. Journée | 29.03.2021 | Cerro Largo | - | Defensor Sporting | 0:0 |
Uruguay
Italie