| 2. Journée | 06.04.2008 | New York RB | - | Columbus Crew | 2:0 | ||||
| 2. Journée | 13.04.2008 | Columbus Crew | - | CD Chivas | 4:3 | ||||
| 2. Journée | 18.04.2008 | D.C. United | - | Columbus Crew | 1:2 | ||||
| 2. Journée | 27.04.2008 | Columbus Crew | - | Houston Dynamo | 1:0 | ||||
| 3. Journée | 04.05.2008 | Columbus Crew | - | Kansas City Wizards | 2:1 | ||||
| 3. Journée | 11.05.2008 | San Jose Earthquakes | - | Columbus Crew | 2:3 | ||||
| 3. Journée | 17.05.2008 | Toronto FC | - | Columbus Crew | 0:0 | ||||
| 3. Journée | 25.05.2008 | Columbus Crew | - | New England Revolution | 0:1 |  |
|||
| 4. Journée | 01.06.2008 | CD Chivas | - | Columbus Crew | 2:0 | ||||
| 4. Journée | 08.06.2008 | Columbus Crew | - | San Jose Earthquakes | 0:2 | ||||
| 6. Journée | 03.08.2008 | Houston Dynamo | - | Columbus Crew | 2:0 | |
|||
| 7. Journée | 28.09.2008 | New England Revolution | - | Columbus Crew | 0:1 | ||||
| 8. Journée | 19.10.2008 | New York RB | - | Columbus Crew | 3:1 | |
Saint-Vincent-et-les-Grenadines