| 2. Journée | 15.03.2021 | Real Potosí | - | Club Aurora | 1:1 |  |
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| 8. Journée | 10.07.2021 | Real Potosí | - | The Strongest | 1:3 | ||||
| 13. Journée | 04.08.2021 | Independiente Petrolero | - | Real Potosí | 2:1 | |
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| 14. Journée | 09.08.2021 | CD Guabirá | - | Real Potosí | 3:0 | |
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| 15. Journée | 14.08.2021 | Real Potosí | - | Blooming | 3:1 | ||||
| 18. Journée | 12.09.2021 | Real Potosí | - | Real Tomayapo | 1:0 |
Bolivie