| Tour préliminaire | 29.11.2020 | PWD Bamenda | - | Kaizer Chiefs | 0:1 |  |
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| Tour préliminaire | 05.12.2020 | Kaizer Chiefs | - | PWD Bamenda | 0:0 | ||||
| 1er tour | 23.12.2020 | Kaizer Chiefs | - | CD 1º de Agosto | 0:0 | ||||
| 1er tour | 05.01.2021 | CD 1º de Agosto | - | Kaizer Chiefs | 0:1 | ||||
| Groupe C | 06.03.2021 | Kaizer Chiefs | - | Petro Atlético | 2:0 | |
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| Groupe C | 16.03.2021 | Petro Atlético | - | Kaizer Chiefs | 0:0 | ||||
| Groupe C | 10.04.2021 | Horoya AC | - | Kaizer Chiefs | 2:2 | ||||
| Quarts de finale | 15.05.2021 | Kaizer Chiefs | - | Simba SC | 4:0 | |
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| Quarts de finale | 22.05.2021 | Simba SC | - | Kaizer Chiefs | 3:0 | ||||
| Demi-finales | 19.06.2021 | Wydad AC | - | Kaizer Chiefs | 0:1 | ||||
| Demi-finales | 26.06.2021 | Kaizer Chiefs | - | Wydad AC | 0:0 | ||||
| Finale | 17.07.2021 | Kaizer Chiefs | - | Al Ahly SC | 0:3 |
Afrique du Sud