| 1. Journée | 05.02.2022 | Defensor Sporting | - | Liverpool | 0:3 |  |
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| 2. Journée | 14.02.2022 | Peñarol | - | Defensor Sporting | 0:1 | ||||
| 3. Journée | 19.02.2022 | Defensor Sporting | - | Montevideo City Torque | 1:3 | ||||
| 4. Journée | 26.02.2022 | Montevideo Wanderers | - | Defensor Sporting | 1:0 | ||||
| 5. Journée | 12.03.2022 | Defensor Sporting | - | Plaza Colonia | 0:0 | ||||
| 6. Journée | 21.03.2022 | Boston River | - | Defensor Sporting | 1:1 |
Uruguay