| 4. Journée | 29.08.2021 | ESTAC Troyes | - | AS Monaco | 1:2 | ||||
| 7. Journée | 22.09.2021 | AS Monaco | - | AS Saint-Étienne | 3:1 | ||||
| 8. Journée | 26.09.2021 | Clermont Foot 63 | - | AS Monaco | 1:3 | ||||
| 9. Journée | 03.10.2021 | AS Monaco | - | Girondins Bordeaux | 3:0 | ||||
| 10. Journée | 16.10.2021 | Olympique Lyonnais | - | AS Monaco | 2:0 | ||||
| 11. Journée | 24.10.2021 | AS Monaco | - | Montpellier HSC | 3:1 | ||||
| 15. Journée | 28.11.2021 | AS Monaco | - | RC Strasbourg | 1:1 | ||||
| 17. Journée | 05.12.2021 | AS Monaco | - | FC Metz | 4:0 | ||||
| 18. Journée | 12.12.2021 | Paris Saint-Germain | - | AS Monaco | 2:0 | ||||
| 19. Journée | 22.12.2021 | AS Monaco | - | Stade Rennais | 2:1 | ||||
| 20. Journée | 09.01.2022 | FC Nantes | - | AS Monaco | 0:0 |  |
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| 22. Journée | 23.01.2022 | Montpellier HSC | - | AS Monaco | 3:2 | ||||
| 23. Journée | 05.02.2022 | AS Monaco | - | Olympique Lyonnais | 2:0 | ||||
| 24. Journée | 13.02.2022 | AS Monaco | - | FC Lorient | 0:0 | ||||
| 26. Journée | 27.02.2022 | AS Monaco | - | Stade de Reims | 1:2 | ||||
| 34. Journée | 23.04.2022 | AS Saint-Étienne | - | AS Monaco | 1:4 | ||||
| 35. Journée | 01.05.2022 | AS Monaco | - | Angers SCO | 2:0 | ||||
| 38. Journée | 21.05.2022 | RC Lens | - | AS Monaco | 2:2 |
Belgique
RD Congo