| 2. Journée | 13.02.2022 | Libertad | - | General Caballero DJLM | 1:0 | ||||
| 3. Journée | 20.02.2022 | General Caballero DJLM | - | Tacuary | 2:0 | ||||
| 4. Journée | 25.02.2022 | Sportivo Ameliano | - | General Caballero DJLM | 1:0 | ||||
| 5. Journée | 04.03.2022 | General Caballero DJLM | - | Club Nacional | 1:2 |  |
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| 6. Journée | 13.03.2022 | Guaraní | - | General Caballero DJLM | 3:1 | ||||
| 7. Journée | 22.03.2022 | General Caballero DJLM | - | Guaireña FC | 0:1 | ||||
| 8. Journée | 03.04.2022 | Sol de América | - | General Caballero DJLM | 2:3 | ||||
| 9. Journée | 10.04.2022 | General Caballero DJLM | - | Cerro Porteño | 0:0 | ||||
| 12. Journée | 24.04.2022 | General Caballero DJLM | - | Club Olimpia | 2:3 | ||||
| 13. Journée | 30.04.2022 | General Caballero DJLM | - | Libertad | 0:1 | ||||
| 14. Journée | 07.05.2022 | Tacuary | - | General Caballero DJLM | 0:0 | ||||
| 15. Journée | 11.05.2022 | General Caballero DJLM | - | Sportivo Ameliano | 0:3 | ||||
| 16. Journée | 14.05.2022 | Club Nacional | - | General Caballero DJLM | 1:2 |
Paraguay