| 1. Journée | 17.02.2021 | Honduras Progreso | - | Marathón | 1:1 | ||||
| 2. Journée | 21.02.2021 | Honduras Progreso | - | Vida | 0:0 | ||||
| 3. Journée | 25.02.2021 | Real España | - | Honduras Progreso | 1:0 | ||||
| 4. Journée | 01.03.2021 | Platense | - | Honduras Progreso | 0:4 |  |
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| 5. Journée | 04.03.2021 | Honduras Progreso | - | Lobos UPNFM | 0:3 | |
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| 6. Journée | 07.03.2021 | Marathón | - | Honduras Progreso | 1:1 | ||||
| 7. Journée | 11.03.2021 | Vida | - | Honduras Progreso | 1:1 | |
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| 8. Journée | 18.03.2021 | Honduras Progreso | - | Real España | 1:1 | |
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| 9. Journée | 22.03.2021 | Honduras Progreso | - | Platense | 2:2 | |
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| 10. Journée | 01.04.2021 | Lobos UPNFM | - | Honduras Progreso | 0:2 | |
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| 11. Journée | 12.04.2021 | Motagua | - | Honduras Progreso | 5:2 | ||||
| 12. Journée | 18.04.2021 | Honduras Progreso | - | Olimpia | 0:5 | ||||
| 13. Journée | 21.04.2021 | Real Sociedad | - | Honduras Progreso | 3:1 | ||||
| 14. Journée | 28.04.2021 | Honduras Progreso | - | Real de Minas | 5:2 | |
Argentine