| 9. Journée | 01.10.2022 | Southampton FC | - | Everton FC | 1:2 | ||||
| 11. Journée | 16.10.2022 | Southampton FC | - | West Ham United | 1:1 | ||||
| 12. Journée | 19.10.2022 | AFC Bournemouth | - | Southampton FC | 0:1 | ||||
| 13. Journée | 23.10.2022 | Southampton FC | - | Arsenal FC | 1:1 | ||||
| 14. Journée | 29.10.2022 | Crystal Palace | - | Southampton FC | 1:0 | ||||
| 15. Journée | 06.11.2022 | Southampton FC | - | Newcastle United | 1:4 | ||||
| 16. Journée | 12.11.2022 | Liverpool FC | - | Southampton FC | 3:1 |  |
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| 19. Journée | 04.01.2023 | Southampton FC | - | Nottingham Forest | 0:1 | ||||
| 20. Journée | 14.01.2023 | Everton FC | - | Southampton FC | 1:2 | ||||
| 21. Journée | 21.01.2023 | Southampton FC | - | Aston Villa | 0:1 | ||||
| 29. Journée | 02.04.2023 | West Ham United | - | Southampton FC | 1:0 | |
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| 32. Journée | 21.04.2023 | Arsenal FC | - | Southampton FC | 3:3 |  |
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| 33. Journée | 27.04.2023 | Southampton FC | - | AFC Bournemouth | 0:1 |
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