| 1. Journée | 13.03.2022 | Rio Grande Valley FC | - | Oakland Roots | 1:0 | ||||
| 1. Journée | 20.03.2022 | Orange County SC | - | Rio Grande Valley FC | 2:1 | ||||
| 1. Journée | 24.03.2022 | Los Angeles Galaxy II | - | Rio Grande Valley FC | 1:0 | ||||
| 1. Journée | 28.03.2022 | Rio Grande Valley FC | - | San Antonio FC | 1:2 | ||||
| 2. Journée | 10.04.2022 | Rio Grande Valley FC | - | Indy Eleven | 1:2 | ||||
| 2. Journée | 24.04.2022 | Rio Grande Valley FC | - | Sacramento Republic | 2:1 | ||||
| 3. Journée | 01.05.2022 | Rio Grande Valley FC | - | Orange County SC | 1:2 | ||||
| 3. Journée | 06.05.2022 | Colorado Springs Switchbacks | - | Rio Grande Valley FC | 3:2 | ||||
| 3. Journée | 22.05.2022 | Rio Grande Valley FC | - | San Diego Loyal | 2:1 | ||||
| 3. Journée | 29.05.2022 | Rio Grande Valley FC | - | San Antonio FC | 2:3 |  |
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| 4. Journée | 02.06.2022 | Atlanta United II | - | Rio Grande Valley FC | 3:4 | ||||
| 4. Journée | 05.06.2022 | Rio Grande Valley FC | - | Los Angeles Galaxy II | 0:1 | ||||
| 4. Journée | 12.06.2022 | Oakland Roots | - | Rio Grande Valley FC | 2:2 | ||||
| 6. Journée | 28.08.2022 | Las Vegas Lights FC | - | Rio Grande Valley FC | 0:5 |
Mexique
États-Unis