| 7. Journée | 11.09.2021 | MŠK Žilina | - | AS Trenčín | 1:3 | ||||
| 12. Journée | 23.10.2021 | Zlaté Moravce | - | AS Trenčín | 0:1 |  |
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| 13. Journée | 31.10.2021 | AS Trenčín | - | Slovan Bratislava | 2:3 | ||||
| 14. Journée | 05.11.2021 | AS Trenčín | - | MFK Zemplín Michalovce | 4:2 |  |
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| 15. Journée | 19.11.2021 | MFK Ružomberok | - | AS Trenčín | 3:0 | ||||
| 16. Journée | 27.11.2021 | AS Trenčín | - | FC DAC 1904 | 0:1 | ||||
| 17. Journée | 04.12.2021 | ŠKF Sereď | - | AS Trenčín | 4:2 | |
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| 18. Journée | 11.12.2021 | AS Trenčín | - | MŠK Žilina | 1:3 |
Slovaquie