| 1. Journée | 03.07.2022 | CD Guabirá | - | Always Ready | 0:1 |  |
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| 2. Journée | 07.07.2022 | Club Aurora | - | CD Guabirá | 1:0 | ||||
| 3. Journée | 12.07.2022 | CD Guabirá | - | Universitario de Sucre | 5:0 | ||||
| 4. Journée | 16.07.2022 | Jorge Wilstermann | - | CD Guabirá | 2:2 | ||||
| 5. Journée | 23.07.2022 | CD Guabirá | - | Nacional Potosí | 2:1 | ||||
| 11. Journée | 21.08.2022 | Blooming | - | CD Guabirá | 1:3 | ||||
| 12. Journée | 24.08.2022 | CD Guabirá | - | Real Tomayapo | 2:1 | |
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| 13. Journée | 27.08.2022 | Atlético Palmaflor | - | CD Guabirá | 2:0 | ||||
| 14. Journée | 31.08.2022 | The Strongest | - | CD Guabirá | 2:3 | ||||
| 16. Journée | 07.09.2022 | Always Ready | - | CD Guabirá | 2:1 | ||||
| 17. Journée | 12.09.2022 | CD Guabirá | - | Club Aurora | 1:1 | |
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| 22. Journée | 12.10.2022 | CD Guabirá | - | Universitario de Vinto | 1:0 | ||||
| 23. Journée | 16.10.2022 | Royal Pari | - | CD Guabirá | 3:2 |
Bolivie