| 1. Journée | 07.02.2022 | River Plate | - | Montevideo Wanderers | 1:1 |  |
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| 6. Journée | 20.03.2022 | Montevideo Wanderers | - | Nacional | 2:2 |  |
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| 8. Journée | 12.04.2022 | Montevideo Wanderers | - | Deportivo Maldonado | 0:1 | ||||
| 9. Journée | 18.04.2022 | Rentistas | - | Montevideo Wanderers | 1:3 | ||||
| 10. Journée | 23.04.2022 | Montevideo Wanderers | - | Liverpool | 0:0 | ||||
| 12. Journée | 15.05.2022 | Montevideo Wanderers | - | Montevideo City Torque | 1:1 | ||||
| 13. Journée | 22.05.2022 | Cerrito | - | Montevideo Wanderers | 0:2 |  |
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| 14. Journée | 29.05.2022 | Plaza Colonia | - | Montevideo Wanderers | 1:0 | ||||
| 15. Journée | 06.06.2022 | Montevideo Wanderers | - | Boston River | 1:2 | |
Uruguay