| 2. Journée | 12.02.2022 | Plaza Colonia | - | River Plate | 0:1 | ||||
| 3. Journée | 19.02.2022 | Cerro Largo | - | Plaza Colonia | 0:5 |  |
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| 4. Journée | 25.02.2022 | Plaza Colonia | - | Fénix | 1:1 | ||||
| 5. Journée | 12.03.2022 | Defensor Sporting | - | Plaza Colonia | 0:0 | ||||
| 8. Journée | 09.04.2022 | Plaza Colonia | - | Danubio | 1:1 | ||||
| 10. Journée | 25.04.2022 | Plaza Colonia | - | Rentistas | 0:3 | ||||
| 14. Journée | 29.05.2022 | Plaza Colonia | - | Montevideo Wanderers | 1:0 | ||||
| 15. Journée | 04.06.2022 | Cerrito | - | Plaza Colonia | 1:1 |
Paraguay