| 1. Journée | 24.07.2021 | NK Veres | - | Kolos Kovalivka | 0:0 | ||||
| 2. Journée | 30.07.2021 | Kolos Kovalivka | - | Metalist 1925 Kharkiv | 1:0 |  |
 |
||
| 4. Journée | 15.08.2021 | Kolos Kovalivka | - | Rukh Lviv | 1:1 | ||||
| 5. Journée | 22.08.2021 | Kolos Kovalivka | - | FK Oleksandriya | 0:1 | ||||
| 6. Journée | 28.08.2021 | Dinamo Kiev | - | Kolos Kovalivka | 7:0 | ||||
| 7. Journée | 12.09.2021 | Kolos Kovalivka | - | FK Mariupol | 1:3 | |
|||
| 8. Journée | 18.09.2021 | Inhulets Petrove | - | Kolos Kovalivka | 0:2 | ||||
| 9. Journée | 24.09.2021 | Kolos Kovalivka | - | Vorskla Poltava | 0:1 | ||||
| 10. Journée | 02.10.2021 | Kolos Kovalivka | - | Chernomorets Odessa | 2:1 | ||||
| 11. Journée | 16.10.2021 | SK Dnipro-1 | - | Kolos Kovalivka | 2:0 | ||||
| 12. Journée | 24.10.2021 | Zorya Lugansk | - | Kolos Kovalivka | 1:0 | ||||
| 13. Journée | 31.10.2021 | Kolos Kovalivka | - | FK Lviv | 0:1 | ||||
| 15. Journée | 21.11.2021 | Desna Chernigov | - | Kolos Kovalivka | 0:1 | ||||
| 3. Journée | 24.11.2021 | FC Mynai | - | Kolos Kovalivka | 1:1 | |
|||
| 17. Journée | 04.12.2021 | Metalist 1925 Kharkiv | - | Kolos Kovalivka | 0:1 | ||||
| 18. Journée | 12.12.2021 | Kolos Kovalivka | - | FC Mynai | 2:1 |
Ukraine