| 1. Journée | 23.02.2025 | Portland Timbers | - | Vancouver Whitecaps | 1:4 | ||||
| 2. Journée | 02.03.2025 | Portland Timbers | - | Austin FC | 1:0 | ||||
| 3. Journée | 09.03.2025 | Nashville SC | - | Portland Timbers | 2:0 |  |
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| 4. Journée | 16.03.2025 | Portland Timbers | - | Los Angeles Galaxy | 1:1 | ||||
| 5. Journée | 23.03.2025 | Colorado Rapids | - | Portland Timbers | 0:3 | ||||
| 6. Journée | 31.03.2025 | Portland Timbers | - | Houston Dynamo | 3:1 | ||||
| 7. Journée | 06.04.2025 | Austin FC | - | Portland Timbers | 0:0 | ||||
| 8. Journée | 13.04.2025 | Sporting Kansas City | - | Portland Timbers | 2:4 |  |
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| 9. Journée | 20.04.2025 | Portland Timbers | - | Los Angeles FC | 3:3 | |
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| 10. Journée | 28.04.2025 | Los Angeles Galaxy | - | Portland Timbers | 2:4 |
Argentine