| 19. Journée | 20.02.2022 | Golden Arrows | - | Cape Town City FC | 0:1 | ||||
| 20. Journée | 02.03.2022 | Orlando Pirates | - | Cape Town City FC | 0:0 | ||||
| 21. Journée | 05.03.2022 | Cape Town City FC | - | Sekhukhune United | 2:1 | ||||
| 3. Journée | 19.03.2022 | Cape Town City FC | - | Marumo Gallants | 1:0 | ||||
| 23. Journée | 03.04.2022 | Cape Town City FC | - | Baroka FC | 5:1 | ||||
| 26. Journée | 27.04.2022 | Mamelodi Sundowns | - | Cape Town City FC | 0:0 | ||||
| 27. Journée | 04.05.2022 | Chippa United | - | Cape Town City FC | 0:0 | ||||
| 28. Journée | 07.05.2022 | Cape Town City FC | - | TS Galaxy | 2:0 |  |
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| 29. Journée | 14.05.2022 | Cape Town City FC | - | AmaZulu FC | 0:0 | ||||
| 30. Journée | 21.05.2022 | Stellenbosch FC | - | Cape Town City FC | 1:0 |
Venezuela