| 9. Journée | 30.11.1980 | AS Roma | - | Udinese Calcio | 3:1 | ||||
| 10. Journée | 14.12.1980 | ACF Fiorentina | - | AS Roma | 1:1 | ||||
| 11. Journée | 21.12.1980 | AS Roma | - | Ascoli Calcio | 4:1 | ||||
| 12. Journée | 28.12.1980 | AC Perugia | - | AS Roma | 1:1 | ||||
| 13. Journée | 18.01.1981 | AS Roma | - | Juventus | 0:0 | ||||
| 14. Journée | 25.01.1981 | AC Pistoiese | - | AS Roma | 0:4 | ||||
| 15. Journée | 01.02.1981 | AS Roma | - | US Avellino | 1:1 | ||||
| 16. Journée | 08.02.1981 | AS Roma | - | Como Calcio | 1:1 | ||||
| 17. Journée | 15.02.1981 | Brescia Calcio | - | AS Roma | 1:2 | ||||
| 18. Journée | 22.02.1981 | AS Roma | - | Bologna FC | 1:1 | ||||
| 21. Journée | 15.03.1981 | AS Roma | - | Inter | 1:0 | ||||
| 22. Journée | 22.03.1981 | US Catanzaro | - | AS Roma | 1:1 | ||||
| 23. Journée | 29.03.1981 | AS Roma | - | Cagliari Calcio | 1:0 | ||||
| 24. Journée | 05.04.1981 | Udinese Calcio | - | AS Roma | 0:2 | ||||
| 25. Journée | 12.04.1981 | AS Roma | - | ACF Fiorentina | 1:1 | ||||
| 26. Journée | 26.04.1981 | Ascoli Calcio | - | AS Roma | 0:0 | ||||
| 27. Journée | 03.05.1981 | AS Roma | - | AC Perugia | 5:0 | ||||
| 28. Journée | 10.05.1981 | Juventus | - | AS Roma | 0:0 | ||||
| 29. Journée | 17.05.1981 | AS Roma | - | AC Pistoiese | 1:0 | ||||
| 30. Journée | 24.05.1981 | US Avellino | - | AS Roma | 1:1 |
Italie