| 1er tour | 29.09.2005 | Aris Saloniki | - | AS Roma | 0:0 | ||||
| Groupe E | 20.10.2005 | Tromsø IL | - | AS Roma | 1:2 |  |
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| Groupe E | 24.11.2005 | AS Roma | - | RC Strasbourg | 1:1 | ||||
| Groupe E | 01.12.2005 | Crvena Zvezda | - | AS Roma | 3:1 | ||||
| Groupe E | 14.12.2005 | AS Roma | - | FC Basel 1893 | 3:1 | ||||
| 3e tour | 15.02.2006 | Club Brugge KV | - | AS Roma | 1:2 |  |
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| tour des 16 | 15.03.2006 | AS Roma | - | Middlesbrough FC | 2:1 |
Italie
