| 1. Journée | 13.03.2022 | Rio Grande Valley FC | - | Oakland Roots | 1:0 | ||||
| 1. Journée | 20.03.2022 | Orange County SC | - | Rio Grande Valley FC | 2:1 |  |
|||
| 1. Journée | 28.03.2022 | Rio Grande Valley FC | - | San Antonio FC | 1:2 | ||||
| 2. Journée | 10.04.2022 | Rio Grande Valley FC | - | Indy Eleven | 1:2 | ||||
| 2. Journée | 16.04.2022 | New York RB II | - | Rio Grande Valley FC | 0:1 | |
|||
| 3. Journée | 15.05.2022 | Monterey Bay FC | - | Rio Grande Valley FC | 1:2 | ||||
| 7. Journée | 11.09.2022 | Rio Grande Valley FC | - | New Mexico United | 3:1 | ||||
| 8. Journée | 06.10.2022 | Memphis 901 | - | Rio Grande Valley FC | 2:2 |
Cuba