| 2. Journée | 22.02.2022 | Deportes Temuco | - | Santiago Wanderers | 1:0 |  |
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| 3. Journée | 02.03.2022 | Santiago Wanderers | - | Santiago Morning | 2:2 | ||||
| 4. Journée | 10.03.2022 | San Luis | - | Santiago Wanderers | 1:1 | ||||
| 5. Journée | 17.03.2022 | Santiago Wanderers | - | Rangers | 1:3 | ||||
| 6. Journée | 22.03.2022 | Fernández Vial | - | Santiago Wanderers | 0:0 | ||||
| 7. Journée | 03.04.2022 | Santiago Wanderers | - | CD Magallanes | 0:2 | |
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| 8. Journée | 09.04.2022 | Deportes Copiapó | - | Santiago Wanderers | 1:1 | ||||
| 9. Journée | 16.04.2022 | Santiago Wanderers | - | Puerto Montt | 2:0 | ||||
| 10. Journée | 21.04.2022 | Deportes Melipilla | - | Santiago Wanderers | 2:0 |  |
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| 14. Journée | 13.05.2022 | Cobreloa | - | Santiago Wanderers | 1:1 | ||||
| 15. Journée | 17.05.2022 | Santiago Wanderers | - | Universidad de Concepción | 0:0 |
Chili