| 2. Journée | 09.02.2021 | River Plate | - | Guaraní | 1:4 | ||||
| 3. Journée | 15.02.2021 | Sol de América | - | River Plate | 1:1 | ||||
| 4. Journée | 19.02.2021 | River Plate | - | Sportivo Luqueño | 1:0 |  |
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| 7. Journée | 10.03.2021 | Cerro Porteño | - | River Plate | 3:0 | ||||
| 8. Journée | 13.03.2021 | River Plate | - | Club Nacional | 0:0 | ||||
| 13. Journée | 27.04.2021 | Sportivo Luqueño | - | River Plate | 2:2 |  |
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| 15. Journée | 10.05.2021 | Guaireña FC | - | River Plate | 0:0 | ||||
| 16. Journée | 16.05.2021 | River Plate | - | Cerro Porteño | 1:1 | ||||
| 17. Journée | 24.05.2021 | Club Nacional | - | River Plate | 0:1 |
Paraguay