| 1. Journée | 27.02.2022 | D.C. United | - | Charlotte FC | 3:0 |  |
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| 2. Journée | 06.03.2022 | Charlotte FC | - | Los Angeles Galaxy | 0:1 | ||||
| 2. Journée | 13.03.2022 | Atlanta United FC | - | Charlotte FC | 2:1 | |
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| 2. Journée | 20.03.2022 | Charlotte FC | - | New England Revolution | 3:1 | ||||
| 2. Journée | 26.03.2022 | Charlotte FC | - | FC Cincinnati | 2:0 | ||||
| 3. Journée | 03.04.2022 | Philadelphia Union | - | Charlotte FC | 2:0 | ||||
| 3. Journée | 10.04.2022 | Charlotte FC | - | Atlanta United FC | 1:0 | ||||
| 3. Journée | 17.04.2022 | New England Revolution | - | Charlotte FC | 2:1 |  |
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| 3. Journée | 24.04.2022 | Colorado Rapids | - | Charlotte FC | 0:0 | |
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| 4. Journée | 01.05.2022 | Orlando City | - | Charlotte FC | 2:1 | ||||
| 4. Journée | 22.05.2022 | Charlotte FC | - | Vancouver Whitecaps | 2:1 | ||||
| 4. Journée | 30.05.2022 | Seattle Sounders | - | Charlotte FC | 2:1 | ||||
| 5. Journée | 11.06.2022 | Charlotte FC | - | New York RB | 2:0 | |
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| 5. Journée | 19.06.2022 | Columbus Crew | - | Charlotte FC | 1:1 | ||||
| 6. Journée | 01.07.2022 | Charlotte FC | - | Austin FC | 0:1 |
Argentine