| 2. Journée | 28.01.2021 | Peñarol | - | Defensor Sporting | 1:2 |  |
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| 3. Journée | 01.02.2021 | Defensor Sporting | - | River Plate | 0:2 | ||||
| 4. Journée | 04.02.2021 | Montevideo City Torque | - | Defensor Sporting | 0:0 | ||||
| 5. Journée | 07.02.2021 | Defensor Sporting | - | Plaza Colonia | 3:2 | |
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| 6. Journée | 11.02.2021 | Progreso | - | Defensor Sporting | 3:3 | ||||
| 8. Journée | 18.02.2021 | CA Cerro | - | Defensor Sporting | 0:0 | ||||
| 9. Journée | 20.02.2021 | Defensor Sporting | - | Liverpool | 0:3 | ||||
| 13. Journée | 18.03.2021 | Deportivo Maldonado | - | Defensor Sporting | 2:1 | ||||
| 14. Journée | 25.03.2021 | Defensor Sporting | - | Rentistas | 0:0 | ||||
| 15. Journée | 29.03.2021 | Cerro Largo | - | Defensor Sporting | 0:0 |
Argentine