| 1. Journée | 03.07.2022 | Nacional Potosí | - | Club Aurora | 3:1 |  |
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| 2. Journée | 06.07.2022 | Always Ready | - | Nacional Potosí | 2:1 | ||||
| 3. Journée | 10.07.2022 | Nacional Potosí | - | The Strongest | 1:5 |  |
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| 4. Journée | 16.07.2022 | Royal Pari | - | Nacional Potosí | 2:2 | ||||
| 5. Journée | 23.07.2022 | CD Guabirá | - | Nacional Potosí | 2:1 | ||||
| 6. Journée | 27.07.2022 | Nacional Potosí | - | Real Santa Cruz | 3:1 | ||||
| 7. Journée | 01.08.2022 | Atlético Palmaflor | - | Nacional Potosí | 0:1 | ||||
| 8. Journée | 07.08.2022 | Nacional Potosí | - | Bolívar | 2:1 | |
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| 15. Journée | 05.09.2022 | Blooming | - | Nacional Potosí | 4:0 | ||||
| 16. Journée | 10.09.2022 | Club Aurora | - | Nacional Potosí | 1:5 | |
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| 17. Journée | 13.09.2022 | Nacional Potosí | - | Always Ready | 1:1 | |
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| 18. Journée | 17.09.2022 | The Strongest | - | Nacional Potosí | 1:1 | |
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| 19. Journée | 01.10.2022 | Nacional Potosí | - | Royal Pari | 1:0 | ||||
| 20. Journée | 05.10.2022 | Nacional Potosí | - | CD Guabirá | 3:1 | |
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| 21. Journée | 08.10.2022 | Real Santa Cruz | - | Nacional Potosí | 2:1 | ||||
| 22. Journée | 12.10.2022 | Nacional Potosí | - | Atlético Palmaflor | 6:1 | |
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| 23. Journée | 15.10.2022 | Bolívar | - | Nacional Potosí | 3:1 | |
Argentine