| 1. Journée | 31.08.2016 | Boston River | - | Defensor Sporting | 1:1 | ||||
| 2. Journée | 04.09.2016 | Defensor Sporting | - | Juventud de Las Piedras | 0:1 | ||||
| 3. Journée | 11.09.2016 | Defensor Sporting | - | Sud América | 2:0 |  |
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| 4. Journée | 18.09.2016 | River Plate | - | Defensor Sporting | 0:5 | ||||
| 5. Journée | 24.09.2016 | Defensor Sporting | - | CA Cerro | 0:1 | |
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| 6. Journée | 02.10.2016 | Defensor Sporting | - | Montevideo Wanderers | 1:1 | |
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| 7. Journée | 09.10.2016 | Fénix | - | Defensor Sporting | 3:1 | |
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| 8. Journée | 16.10.2016 | Defensor Sporting | - | Liverpool | 1:3 | ||||
| 9. Journée | 23.10.2016 | Plaza Colonia | - | Defensor Sporting | 0:1 | ||||
| 12. Journée | 20.11.2016 | Defensor Sporting | - | Nacional | 3:2 | |
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| 14. Journée | 04.12.2016 | Defensor Sporting | - | Racing | 2:1 |
Uruguay