| 1. Journée | 25.08.2012 | River Plate | - | Juventud de Las Piedras | 1:0 | ||||
| 2. Journée | 02.09.2012 | Peñarol | - | River Plate | 1:1 |  |
 |
||
| 3. Journée | 16.09.2012 | River Plate | - | Racing | 2:2 | ||||
| 4. Journée | 23.09.2012 | El Tanque Sisley | - | River Plate | 1:0 | ||||
| 5. Journée | 30.09.2012 | River Plate | - | Liverpool | 2:0 | ||||
| 6. Journée | 07.10.2012 | River Plate | - | Montevideo Wanderers | 1:3 | ||||
| 7. Journée | 13.10.2012 | River Plate | - | Progreso | 0:0 | |
|||
| 8. Journée | 20.10.2012 | River Plate | - | Bella Vista | 0:2 | ||||
| 9. Journée | 28.10.2012 | Cerro Largo | - | River Plate | 2:2 | ||||
| 10. Journée | 03.11.2012 | Nacional | - | River Plate | 0:2 | |
|||
| 11. Journée | 10.11.2012 | River Plate | - | CA Cerro | 0:1 | ||||
| 12. Journée | 17.11.2012 | Danubio | - | River Plate | 0:2 | ||||
| 13. Journée | 24.11.2012 | River Plate | - | Defensor Sporting | 1:1 | ||||
| 14. Journée | 02.12.2012 | Central Español | - | River Plate | 2:5 | ||||
| 15. Journée | 08.12.2012 | Fénix | - | River Plate | 2:2 | |
Uruguay