| 1. Journée | 02.08.2021 | Kilmarnock FC | - | Ayr United | 2:0 | ||||
| 2. Journée | 07.08.2021 | Ayr United | - | Arbroath FC | 2:2 | ||||
| 3. Journée | 21.08.2021 | Inverness CT | - | Ayr United | 1:0 | ||||
| 5. Journée | 11.09.2021 | Ayr United | - | Dunfermline Athletic | 3:1 |  |
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| 6. Journée | 18.09.2021 | Hamilton Academical | - | Ayr United | 0:2 | ||||
| 7. Journée | 25.09.2021 | Ayr United | - | Greenock Morton FC | 0:0 | ||||
| 8. Journée | 02.10.2021 | Partick Thistle | - | Ayr United | 4:0 | ||||
| 16. Journée | 04.12.2021 | Greenock Morton FC | - | Ayr United | 2:2 | ||||
| 17. Journée | 10.12.2021 | Ayr United | - | Hamilton Academical | 1:1 |
Angleterre