| 2. Journée | 07.08.2021 | Cobán Imperial | - | Sololá FC | 0:0 | ||||
| 4. Journée | 14.08.2021 | Cobán Imperial | - | Achuapa | 2:0 |  |
|||
| 3. Journée | 18.08.2021 | Nueva Concepción | - | Cobán Imperial | 2:1 | ||||
| 6. Journée | 25.08.2021 | Deportivo Malacateco | - | Cobán Imperial | 1:0 | ||||
| 7. Journée | 29.08.2021 | Cobán Imperial | - | Antigua GFC | 0:2 | ||||
| 9. Journée | 11.09.2021 | Cobán Imperial | - | Santa Lucía | 0:1 | ||||
| 10. Journée | 18.09.2021 | CSD Municipal | - | Cobán Imperial | 2:1 | ||||
| 11. Journée | 25.09.2021 | Cobán Imperial | - | Iztapa | 2:1 | |
|||
| 8. Journée | 13.10.2021 | Deportivo Guastatoya | - | Cobán Imperial | 0:1 | ||||
| 14. Journée | 17.10.2021 | Cobán Imperial | - | Nueva Concepción | 2:0 | ||||
| 15. Journée | 23.10.2021 | Achuapa | - | Cobán Imperial | 1:0 | ||||
| 16. Journée | 27.10.2021 | Cobán Imperial | - | Comunicaciones | 1:2 | |
|||
| 17. Journée | 31.10.2021 | Cobán Imperial | - | Deportivo Malacateco | 1:1 | ||||
| 18. Journée | 07.11.2021 | Antigua GFC | - | Cobán Imperial | 2:1 | ||||
| 19. Journée | 13.11.2021 | Cobán Imperial | - | Deportivo Guastatoya | 0:1 | |
|||
| 21. Journée | 28.11.2021 | Cobán Imperial | - | CSD Municipal | 0:1 | ||||
| 22. Journée | 05.12.2021 | Iztapa | - | Cobán Imperial | 5:3 |
Guatemala