| 1. Journée | 18.09.2021 | Club Tijuana [] | - | Pumas UNAM [] | 1:2 | ||||
| 3. Journée | 02.10.2021 | Deportivo Toluca [] | - | Club Tijuana [] | 3:0 | ||||
| 5. Journée | 16.10.2021 | CF América [] | - | Club Tijuana [] | 6:0 | ||||
| 6. Journée | 23.10.2021 | Club Tijuana [] | - | CF Pachuca [] | 4:2 | ||||
| 7. Journée | 30.10.2021 | Club Tijuana [] | - | Gallos Blancos [] | 3:0 | ||||
| 10. Journée | 20.11.2021 | Club Tijuana [] | - | Cruz Azul [] | 1:2 |
Mexique