| 1. Journée | 15.08.2021 | Southampton FC U23 | - | Norwich City U23 | 0:3 |  |
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| 5. Journée | 19.09.2021 | Southampton FC U23 | - | Burnley FC U23 | 0:2 | |
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| 6. Journée | 27.09.2021 | Birmingham City U23 | - | Southampton FC U23 | 3:2 |  |
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| 8. Journée | 18.10.2021 | Wolverhampton Wanderers U23 | - | Southampton FC U23 | 0:1 | ||||
| 9. Journée | 25.10.2021 | Reading FC U23 | - | Southampton FC U23 | 0:1 | |
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| 10. Journée | 31.10.2021 | Southampton FC U23 | - | Aston Villa U23 | 4:0 | |
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| 12. Journée | 21.11.2021 | Sunderland AFC U23 | - | Southampton FC U23 | 3:2 | |
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| 13. Journée | 28.11.2021 | Southampton FC U23 | - | West Bromwich Albion U23 | 3:1 | ||||
| 14. Journée | 06.12.2021 | Stoke City U23 | - | Southampton FC U23 | 3:0 |
Angleterre