| 4. Journée | 22.07.2021 | Portland Timbers | - | Los Angeles FC | 2:1 | ||||
| 5. Journée | 05.08.2021 | Los Angeles FC | - | Sporting Kansas City | 1:4 | ||||
| 5. Journée | 09.08.2021 | San Jose Earthquakes | - | Los Angeles FC | 2:1 | ||||
| 5. Journée | 15.08.2021 | Atlanta United FC | - | Los Angeles FC | 1:0 | ||||
| 5. Journée | 22.08.2021 | Vancouver Whitecaps | - | Los Angeles FC | 2:1 | ||||
| 5. Journée | 29.08.2021 | Los Angeles FC | - | Los Angeles Galaxy | 3:3 |  |
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| 6. Journée | 16.09.2021 | Austin FC | - | Los Angeles FC | 1:2 | ||||
| 6. Journée | 20.09.2021 | Portland Timbers | - | Los Angeles FC | 2:1 | ||||
| 7. Journée | 04.10.2021 | Los Angeles Galaxy | - | Los Angeles FC | 1:1 | ||||
| 7. Journée | 16.10.2021 | Los Angeles FC | - | San Jose Earthquakes | 3:1 | ||||
| 7. Journée | 21.10.2021 | FC Dallas | - | Los Angeles FC | 2:3 | ||||
| 7. Journée | 24.10.2021 | Minnesota United FC | - | Los Angeles FC | 1:1 | ||||
| 7. Journée | 27.10.2021 | Los Angeles FC | - | Seattle Sounders | 3:0 | |
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| 8. Journée | 03.11.2021 | Los Angeles FC | - | Vancouver Whitecaps | 1:1 |  |
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| 8. Journée | 08.11.2021 | Colorado Rapids | - | Los Angeles FC | 5:2 | |
Uruguay