| 1. Journée | 01.08.2021 | Once Municipal | - | CD Águila | 2:2 |  |
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| 2. Journée | 08.08.2021 | Jocoro FC | - | Once Municipal | 3:4 |  |
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| 3. Journée | 11.08.2021 | Once Municipal | - | Municipal Limeño | 4:1 | ||||
| 4. Journée | 15.08.2021 | Platense Zacatecoluca | - | Once Municipal | 1:1 | |
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| 6. Journée | 25.08.2021 | Luis Ángel Firpo | - | Once Municipal | 2:2 | ||||
| 7. Journée | 29.08.2021 | AD Chalatenango | - | Once Municipal | 1:2 | ||||
| 5. Journée | 10.09.2021 | Alianza | - | Once Municipal | 1:0 | ||||
| 8. Journée | 12.09.2021 | Once Municipal | - | FAS | 1:3 | |
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| 11. Journée | 26.09.2021 | Santa Tecla FC | - | Once Municipal | 0:1 | ||||
| 12. Journée | 03.10.2021 | CD Águila | - | Once Municipal | 1:2 | ||||
| 14. Journée | 09.10.2021 | Municipal Limeño | - | Once Municipal | 1:1 | ||||
| 13. Journée | 17.10.2021 | Once Municipal | - | Jocoro FC | 2:2 |  |
El Salvador