| 2. Journée | 28.01.2021 | ART Municipal Jalapa | - | Junior Managua | 1:1 | ||||
| 7. Journée | 14.02.2021 | ART Municipal Jalapa | - | Club Deportivo Ocotal | 3:3 | ||||
| 8. Journée | 18.02.2021 | Chinandega | - | ART Municipal Jalapa | 1:1 | ||||
| 9. Journée | 28.02.2021 | ART Municipal Jalapa | - | Real Madriz | 4:1 |  |
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| 10. Journée | 08.03.2021 | ART Municipal Jalapa | - | Juventus Managua | 1:0 | ||||
| 11. Journée | 14.03.2021 | Junior Managua | - | ART Municipal Jalapa | 2:1 | ||||
| 12. Journée | 01.04.2021 | CD Walter Ferretti | - | ART Municipal Jalapa | 4:0 |  |
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| 14. Journée | 20.04.2021 | Real Estelí FC | - | ART Municipal Jalapa | 1:0 | ||||
| 15. Journée | 26.04.2021 | ART Municipal Jalapa | - | Managua FC | 2:2 | ||||
| 16. Journée | 30.04.2021 | Club Deportivo Ocotal | - | ART Municipal Jalapa | 2:0 |  |
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| 17. Journée | 03.05.2021 | ART Municipal Jalapa | - | Chinandega | 1:1 | ||||
| 18. Journée | 05.05.2021 | Real Madriz | - | ART Municipal Jalapa | 1:0 |
Nicaragua