| 1. Journée | 25.06.2022 | Mazatlán FC [] | - | Club Tijuana [] | 0:3 | ||||
| 2. Journée | 02.07.2022 | CF Monterrey [] | - | Mazatlán FC [] | 4:1 |  |
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| 3. Journée | 09.07.2022 | Mazatlán FC [] | - | Atlético San Luis [] | 1:2 | ||||
| 5. Journée | 23.07.2022 | Santos Laguna [] | - | Mazatlán FC [] | 5:0 | ||||
| 6. Journée | 30.07.2022 | Mazatlán FC [] | - | Atlas Guadalajara [] | 2:5 | |
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| 7. Journée | 06.08.2022 | UANL Tigres [] | - | Mazatlán FC [] | 2:1 | |
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| 8. Journée | 13.08.2022 | Mazatlán FC [] | - | Club León [] | 3:0 | |
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| 9. Journée | 20.08.2022 | Deportivo Guadalajara [] | - | Mazatlán FC [] | 4:1 | ||||
| 10. Journée | 27.08.2022 | Club Tijuana [] | - | Mazatlán FC [] | 4:0 | |
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| 11. Journée | 03.09.2022 | Mazatlán FC [] | - | Deportivo Guadalajara [] | 2:8 | ||||
| 12. Journée | 10.09.2022 | Club León [] | - | Mazatlán FC [] | 1:0 | |
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| 13. Journée | 17.09.2022 | Mazatlán FC [] | - | UANL Tigres [] | 0:3 | ||||
| 14. Journée | 24.09.2022 | Atlas Guadalajara [] | - | Mazatlán FC [] | 3:1 | ||||
| 15. Journée | 01.10.2022 | Mazatlán FC [] | - | Santos Laguna [] | 2:3 | |
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| 17. Journée | 15.10.2022 | Atlético San Luis [] | - | Mazatlán FC [] | 2:2 | ||||
| 18. Journée | 22.10.2022 | Mazatlán FC [] | - | CF Monterrey [] | 0:4 |
Mexique