| 2. Journée | 02.05.2021 | San Antonio FC | - | Colorado Springs Switchbacks | 3:0 | ||||
| 3. Journée | 06.06.2021 | Colorado Springs Switchbacks | - | San Antonio FC | 1:1 | ||||
| 3. Journée | 12.06.2021 | Las Vegas Lights FC | - | San Antonio FC | 1:1 | ||||
| 3. Journée | 17.06.2021 | New Mexico United | - | San Antonio FC | 2:0 | ||||
| 3. Journée | 20.06.2021 | San Antonio FC | - | Rio Grande Valley FC | 1:1 | ||||
| 3. Journée | 27.06.2021 | Real Monarchs SLC | - | San Antonio FC | 1:1 | ||||
| 4. Journée | 17.07.2021 | Colorado Springs Switchbacks | - | San Antonio FC | 2:3 | ||||
| 4. Journée | 29.07.2021 | San Antonio FC | - | El Paso Locomotive | 1:2 |  |
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| 4. Journée | 01.08.2021 | Austin Bold | - | San Antonio FC | 0:3 | ||||
| 5. Journée | 09.08.2021 | Rio Grande Valley FC | - | San Antonio FC | 1:2 | ||||
| 6. Journée | 08.09.2021 | Austin Bold | - | San Antonio FC | 2:1 | |
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| 6. Journée | 12.09.2021 | Real Monarchs SLC | - | San Antonio FC | 0:1 | ||||
| 6. Journée | 19.09.2021 | Sacramento Republic | - | San Antonio FC | 0:1 | ||||
| 6. Journée | 26.09.2021 | San Antonio FC | - | New Mexico United | 0:1 | |
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| 7. Journée | 07.10.2021 | El Paso Locomotive | - | San Antonio FC | 3:3 |
Suède