| 3. Journée | 20.02.2022 | Árabe Unido | - | Sporting San Miguelito | 0:0 | ||||
| 5. Journée | 05.03.2022 | Sporting San Miguelito | - | Potros del Este | 1:1 |  |
|||
| 6. Journée | 08.03.2022 | UD Universitario | - | Sporting San Miguelito | 0:2 | ||||
| 7. Journée | 13.03.2022 | Sporting San Miguelito | - | Herrera FC | 1:1 | ||||
| 10. Journée | 04.04.2022 | Sporting San Miguelito | - | Atlético Chiriquí | 4:1 | ||||
| 13. Journée | 23.04.2022 | Plaza Amador | - | Sporting San Miguelito | 1:1 | ||||
| 12. Journée | 04.05.2022 | Sporting San Miguelito | - | Tauro FC | 0:1 |
Panama