| 1. Journée | 05.03.2022 | MFK Zemplín Michalovce | - | AS Trenčín | 1:0 | ||||
| 2. Journée | 12.03.2022 | FK Senica | - | MFK Zemplín Michalovce | 2:1 | ||||
| 3. Journée | 19.03.2022 | MFK Zemplín Michalovce | - | Zlaté Moravce | 1:0 | ||||
| 4. Journée | 02.04.2022 | MFK Zemplín Michalovce | - | FK Pohronie | 1:0 | ||||
| 5. Journée | 08.04.2022 | Tatran Liptovský Mikuláš | - | MFK Zemplín Michalovce | 3:1 | ||||
| 6. Journée | 18.04.2022 | Zlaté Moravce | - | MFK Zemplín Michalovce | 1:1 |  |
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| 7. Journée | 23.04.2022 | MFK Zemplín Michalovce | - | FK Senica | 1:0 | ||||
| 10. Journée | 21.05.2022 | AS Trenčín | - | MFK Zemplín Michalovce | 2:2 |  |
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