| 13. Journée | 28.07.2021 | Cobresal | - | Deportes Melipilla | 1:1 | ||||
| 16. Journée | 15.08.2021 | Everton | - | Deportes Melipilla | 1:2 | ||||
| 17. Journée | 22.08.2021 | Deportes Melipilla | - | Huachipato | 1:2 | ||||
| 24. Journée | 04.10.2021 | Deportes Melipilla | - | Santiago Wanderers | 1:1 | ||||
| 26. Journée | 17.10.2021 | Deportes Melipilla | - | La Serena | 1:1 |  |
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| 27. Journée | 20.10.2021 | O'Higgins | - | Deportes Melipilla | 1:2 | ||||
| 28. Journée | 24.10.2021 | Deportes Melipilla | - | Universidad de Chile | 3:0 | ||||
| 29. Journée | 01.11.2021 | Unión La Calera | - | Deportes Melipilla | 2:3 | |
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| 30. Journée | 03.11.2021 | Deportes Melipilla | - | Cobresal | 2:1 | ||||
| 31. Journée | 10.11.2021 | Colo-Colo | - | Deportes Melipilla | 1:0 | |
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| 33. Journée | 27.11.2021 | Deportes Melipilla | - | Everton | 1:0 | |
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| 34. Journée | 05.12.2021 | Huachipato | - | Deportes Melipilla | 3:1 |
Chili