| 3. Journée | 14.08.2022 | Montevideo City Torque | - | Defensor Sporting | 0:2 | ||||
| 8. Journée | 16.09.2022 | Defensor Sporting | - | Cerro Largo | 0:1 | ||||
| 9. Journée | 20.09.2022 | Fénix | - | Defensor Sporting | 0:0 |  |
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| 11. Journée | 02.10.2022 | Defensor Sporting | - | Albion | 2:0 | ||||
| 12. Journée | 09.10.2022 | Nacional | - | Defensor Sporting | 1:1 | ||||
| 13. Journée | 13.10.2022 | Defensor Sporting | - | Danubio | 1:1 | ||||
| 14. Journée | 15.10.2022 | Deportivo Maldonado | - | Defensor Sporting | 0:0 | ||||
| 15. Journée | 22.10.2022 | Defensor Sporting | - | Rentistas | 2:3 |
Uruguay