| 6. Journée | 21.08.2022 | Defensor Sporting | - | Boston River | 0:1 | ||||
| 5. Journée | 28.08.2022 | Plaza Colonia | - | Defensor Sporting | 0:1 | ||||
| 4. Journée | 03.09.2022 | Defensor Sporting | - | Montevideo Wanderers | 1:0 | ||||
| 7. Journée | 11.09.2022 | River Plate | - | Defensor Sporting | 0:1 | ||||
| 8. Journée | 16.09.2022 | Defensor Sporting | - | Cerro Largo | 0:1 | ||||
| 9. Journée | 20.09.2022 | Fénix | - | Defensor Sporting | 0:0 | ||||
| 10. Journée | 26.09.2022 | Cerrito | - | Defensor Sporting | 1:2 | ||||
| 12. Journée | 09.10.2022 | Nacional | - | Defensor Sporting | 1:1 |  |
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| 13. Journée | 13.10.2022 | Defensor Sporting | - | Danubio | 1:1 | ||||
| 14. Journée | 15.10.2022 | Deportivo Maldonado | - | Defensor Sporting | 0:0 | |
Uruguay