| 4. Journée | 26.02.2023 | Defensor Sporting | - | Peñarol | 2:2 |  |
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| 6. Journée | 13.03.2023 | Defensor Sporting | - | Liverpool | 2:2 | |
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| 7. Journée | 19.03.2023 | Cerro Largo | - | Defensor Sporting | 0:3 | |
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| 8. Journée | 25.03.2023 | Defensor Sporting | - | Plaza Colonia | 4:0 | ||||
| 9. Journée | 03.04.2023 | Racing | - | Defensor Sporting | 0:1 | ||||
| 10. Journée | 08.04.2023 | Defensor Sporting | - | CA Cerro | 1:1 | ||||
| 11. Journée | 16.04.2023 | Boston River | - | Defensor Sporting | 1:0 | ||||
| 12. Journée | 23.04.2023 | Defensor Sporting | - | Deportivo Maldonado | 1:1 | |
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| 13. Journée | 30.04.2023 | River Plate | - | Defensor Sporting | 0:4 | ||||
| 14. Journée | 07.05.2023 | Defensor Sporting | - | Nacional | 2:2 | ||||
| 15. Journée | 14.05.2023 | Danubio | - | Defensor Sporting | 1:1 |
Uruguay