| 1. Journée | 06.02.2022 | Boston River | - | Plaza Colonia | 0:0 |  |
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| 2. Journée | 12.02.2022 | Plaza Colonia | - | River Plate | 0:1 | ||||
| 5. Journée | 12.03.2022 | Defensor Sporting | - | Plaza Colonia | 0:0 | ||||
| 6. Journée | 20.03.2022 | Plaza Colonia | - | Albion | 1:1 | |
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| 7. Journée | 02.04.2022 | Nacional | - | Plaza Colonia | 1:0 | |
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| 8. Journée | 09.04.2022 | Plaza Colonia | - | Danubio | 1:1 | ||||
| 9. Journée | 17.04.2022 | Deportivo Maldonado | - | Plaza Colonia | 3:1 | |
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| 10. Journée | 25.04.2022 | Plaza Colonia | - | Rentistas | 0:3 | ||||
| 11. Journée | 07.05.2022 | Liverpool | - | Plaza Colonia | 1:0 | ||||
| 12. Journée | 14.05.2022 | Plaza Colonia | - | Peñarol | 0:1 | ||||
| 13. Journée | 24.05.2022 | Montevideo City Torque | - | Plaza Colonia | 1:1 | |
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| 15. Journée | 04.06.2022 | Cerrito | - | Plaza Colonia | 1:1 |
Uruguay