| 8. Journée | 11.07.2021 | Always Ready | - | Atlético Palmaflor | 3:2 |  |
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| 9. Journée | 18.07.2021 | Independiente Petrolero | - | Always Ready | 1:2 | ||||
| 10. Journée | 21.07.2021 | Royal Pari | - | Always Ready | 2:1 | ||||
| 11. Journée | 24.07.2021 | Always Ready | - | Real Potosí | 2:1 | ||||
| 12. Journée | 01.08.2021 | CD Guabirá | - | Always Ready | 0:0 | ||||
| 13. Journée | 04.08.2021 | Always Ready | - | Blooming | 5:1 | |
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| 14. Journée | 09.08.2021 | Bolívar | - | Always Ready | 0:2 | |
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| 6. Journée | 11.08.2021 | Always Ready | - | The Strongest | 2:1 | ||||
| 17. Journée | 21.08.2021 | Club San José | - | Always Ready | 0:4 | ||||
| 18. Journée | 14.09.2021 | Always Ready | - | Real Santa Cruz | 4:0 | ||||
| 21. Journée | 27.09.2021 | The Strongest | - | Always Ready | 1:1 | ||||
| 22. Journée | 20.10.2021 | Always Ready | - | Jorge Wilstermann | 0:0 | |
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| 24. Journée | 27.10.2021 | Always Ready | - | Independiente Petrolero | 2:2 | |
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| 26. Journée | 21.11.2021 | Real Potosí | - | Always Ready | 3:2 | |
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| 28. Journée | 01.12.2021 | Blooming | - | Always Ready | 1:2 | ||||
| 29. Journée | 05.12.2021 | Always Ready | - | Bolívar | 1:1 | ||||
| 30. Journée | 12.12.2021 | Club Aurora | - | Always Ready | 3:4 |
Colombie